TOXICOLOGY AND APPLIED PHARMACOLOGY 15,62-68(1969) The Subacute Toxicity of i,l-Dimethylhydrazine
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چکیده
The Subacute Toxicity of l,l-Dimethylhydrazine. CORNISH, HERBERT H., and HARTUNG, ROLF (1969). Toxicol. Appl. Pharmacol. 15, 62-68. Daily injections of 70,50,30, or 10 mg UDMH/kg resulted in the death of 9,6, 5, and 0 rats, respectively, in each group of 10. All deaths occurred within the first 3 days. Animals surviving the first 3 days began to gain weight even though daily dosing was continued. Animals receiving more than 10 mg/kg/day were markedly diuretic throughout the 21-day experimental period. Blood urea nitrogen and serum glutamic-oxaloacetic transaminase (SGOT) levels were significantly elevated in the 50 mg/kg dose group at 21 days. SGOT also appeared somewhat elevated in the 30 mg/kg/ day group. Histopathologic studies showed some evidence of early lipid infiltration in the tubular epithelium of the kidney. Thus, although some animals appear to adjust to relatively high daily doses of UDMH, biochemical and histologic evidence indicates mild kidney damage in these animals.
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